Portree is set to be the location for a VisitScotland regional hub.
VisitScotland said 39 of its 65 centres would shut over the next two years, leaving 26 "high impact regional hubs" in response to the popularity of digital services over information centres.
Decisions regarding the location of the regional hubs in Dumfries and Galloway, the Scottish Borders and the Outer Hebrides are to be made following a consultation with the local tourism industry over the coming months.
In the meantime, sites located in Peebles, Jedburgh, Gretna, Kirkcudbright, Dumfries, Tarbert (Harris) and Stornoway will continue to operate as normal for now.
VisitScotland said there had been a significant decline in the number of tourists visiting their information centres, amounting to a 58% drop in footfall over the past 10 years.
The 26 regional hubs will operate in locations of greatest visitor demand and offer information about attractions across wider regions, said VisitScotland.
The current number of information centres will be replaced with 1,500 "information partners", made up of local businesses, such as bed and breakfasts, distilleries or local retailers.
New Regional Hubs:
Dumfries and Galloway
Centres to close over next two years:
Tarbert (Loch Fyne)